Endocrine Abstracts

Introduction: Diabetes and dyslipidemia are two common comorbid conditions encountered in clinical practice. Diabetes is considered as a cardiovascular disease (CVD) equivalent. Most professional organizations suggest statin therapy for diabetic patients, regardless of baseline lipid levels for patients with overt cardiovascular disease or without CVD over 40 years and have one or more other CVD risk factors. For lower risk patients;the LDL goal is 100 mg/dl and for patients w...

Aim: In this study we aimed to investigate general properties and treatment modalities of our type 2 diabetic patients.Materials and methods: A total of 136 consecutive type 2 diabetic patients were investigated. Type 2 diabetic patients were divided into three different groups according to HbA1c level (<7% group 1, 7–9% group 2, >9% group 3).Results: Mean age of our type 2 diabetic patients (F n=95, M n</...

Objective: Our aim is to evaluate the effect of exenatide treatment on body weight, HbA1c and compliance to treatment.Material and method: A total of 36 (five M and 31 F) type 2 diabetic patients who were prescribed exenatide were evaluated for this study. Body weight, BMI, HbA1c parameters and side effects were noted from the outpatient clinic records.Result: The median age of our patients was 52 years of old (19–79 years). M...

Introduction: Hypokalemic periodic paralysis (HPP), is a rare neuromuscular disorder caused by dysfunction of the ion channels in red muscle cells which is characterized by painless episodes of muscle weakness generally after strenuous exertion or a high-carbohydrate meal. However, some HPP patients secondary to thyrotoxicosis are also described.Case: A 41-year-old Caucasian man, without any chronic disease, presented to our emergency department with gen...

Purpose: Irisin is a secreted protein implicated in the regulation of insulin sensitivity and energy metabolism. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance, dyslipidemia, glucose metabolism dysfunction and obesity. There is also some evidence of a link between irisin and inflammation. Our aim of the study to ascertain whether the association of circulating irisin levels with inflammatory markers in PCOS.<p...

Introduction: Association between ankle-brachial index (ABI) and coronary, cerebral, and peripheral vessels involvement has been shown in different studies. The normal range of ABI is between 0.9 and 1.4. Values below 0.9 show peripheral vessel disease. An ABI more than 1.4 is characteristic for vascular rigidity. We aimed to investigate the ABI value in our type 2 diabetic patients and association of ABI with glycemic control.Materials and methods: This...

Thyroid cancer in Turkey is the most common endocrine neoplasm with an incidence of 3.7%. Papillary thyroid carcinoma is the most common thyroid malignancy in a similar manner. Papillary thyroid carcinoma creates 50–90% of differentiated thyroid carcinomas. There is available in subgroups with poor prognosis. Case-specific mortality of 2% at 5, 10, and 20 years, only 4 and 5%.Mutations and re-arrangements in genes encoding proteins of the MAPK pathw...

Context: Betatrophin is a newly identified hormone appreciated for its role as a potent inducer of beta cell proliferation in line with insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence was available whether betatrophin is involved in women with PCOS.Objective: To ascertain whether betatrophin levels are altered in women with PCOS.<p class="...

Aim: Bisphenol A (BPA) is the most common endocrine disruptor among environmental estrogens. BPA is an ingredient that is commonly used in polycarbonate plastics. In this study, our main concern is to measure the levels of BPA in premenopausal obese women and to examine the relationship of BPA with adiponectin and leptin.Materials and methods: 47 obese women and 39 non-obese healthy women were enrolled in this study. All participants were premenopausal. ...

Context: Adipsin, a protein secreted mainly from the adipose tissue, is a structural homologous of complement factor D, a rate-limiting enzyme of the alternative complement system. Growing evidence suggests that the alternative complement system plays a role both in the regulation of energy homeostasis and the atherosclerotic process. Polycystic ovary syndrome (PCOS) is an inflammatory based-metabolic disease.Objective: To ascertain whether circulating a...